Highly efficient synthesis of carboacyclic nucleosides catalyzed by zinc oxide in 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br)

Document Type: Articles

Authors

1 Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran.

2 Department of Chemistry, University of Sayyed Jamaleddin Asadabadi, Asadabad, 6541835583, Iran.

Abstract

Michael addition of pyrimidine and purine nucleobases to substituted as well as unsubstituted α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of zinc oxide in ionic liquid 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br) under microwave irradiation to afford carboacyclic nucleosides, as biologically important compounds, in good to excellent yields and in short reaction times.

Keywords


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