Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity

Youseftabar-Miri, Leila; Rafieirad, Maryam

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	Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity
Article 3, Volume 5, Issue 1, Winter 2015, Page 15-19 PDF (721.01 K)
Document Type: Letters
Authors
Leila Youseftabar-Miri ¹; Maryam Rafieirad²
¹Department of Chemistry, Izeh Branch, Islamic Azad University, Izeh, Iran
²Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
Abstract
The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity.(The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity, i try to submit paper)
Keywords
Ionic Liquid; Henry reaction; Oxindole; Isatin


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