Et3N as a catalyst for the synthesis of indeno[1,2-b]chromene derivatives via three-component condensation reaction

Document Type : Articles


1 Department of Chemistry, Jouybar Branch, Islamic Azad University, Jouybar, Iran.

2 Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.


Functionalized indeno[1,2-b]chromene derivatives have been synthesized via condensation reaction of 1H-indene-1,3(2H)-dione with benzaldehyde and cyclization with 2-hydroxynaphthalene-1,4-dione in the presence of a catalytic amount of triethylamine (Et3N) in EtOH at room temperature. It was observed that benzaldehyde bearing electron donating group gave high yield of product, whereas, benzaldehyde having electronic withdrawing substituent does not participate in this reaction. The structures were confirmed spectroscopically (IR, 1H- and 13C-NMR, and Mass). A plausible mechanism for this reaction is proposed (Scheme 2). Good yields and easy purification are the main advantages of the present method. Products of these reactions have structural similarity to naturally occurring pyranokunthone B, lambertellin, β-lapachone, and α-xiloidone.


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Volume 5, Issue 4 - Serial Number 4
December 2015
Pages 345-350
  • Receive Date: 28 January 2015
  • Revise Date: 27 April 2015
  • Accept Date: 15 May 2015
  • First Publish Date: 01 December 2015